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Structure, dynamics, evolution and catalysis of phosphohexomutase from Pseudomonas aeruginosa
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] [alpha]-D phosphohexomutases are ubiquitous in the environment and participate in carbohydrate metabolism by catalyzing an intramolecular phosphoryl transfer. Biophysical...
Conformational studies on adenine formation and spin properties of bio-related radicals
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] This dissertation summarizes a few different projects I have contributed to in Dr. Glaser's group during the past five years. The first part is chapter 2 and 3, which describe...
Closomers at a click : a treatise on the design, synthesis and in vivo MRI of novel click closomers as high performance and efficacious contrast agents
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The advent of Magnetic Resonance Imaging or MRI has truly revolutionized the field of medical diagnostic and imaging. The signal intensity and the overall detail and clarity...
Sythesis, characterization and reactivity of platinum (II) peroxo, alkoxide and triflate compunds
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The chemistry of a collection of platinum(II) compounds, including peroxo, alkoxide and triflate compounds, were synthesized and studied. This involved a rather wide range...
Fluorescent sensors for lipids and hydrophobic amines in aqueous solution
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] A series of novel fluorescent sensors were designed and synthesized to detect lipids and hydrophobic amines in aqueous solutions. The closed allyl molecular tubes had fairly high...
Synthesis, characterisation photophysical and DFT studies of 2,2'-diphenylenegold(III) diethyldithiocarbamate
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Cyclometalated gold(III) complexes have been demonstrated to show electroluminescence properties and have been employed as electrophosphorescent materials in organic light...
The synthesis of a fluorescent bioconjugation agent
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Bioconjugation linkers are used covalently link two molecules, where at least one is a large biomolecule for uses such as tracking cellular function, imaging biomarkers...
Finite element analysis for the insertion process of the press-fitted total hip arthroplasty
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] There are more than 300,000 total hip arthroplasty (THA) surgeries performed every year in the United States. Press-fitted artificial hip joints are wildly used for relatively...
Diverse applications of covalent cross-links in duplex DNA: From anti-cancer drugs to the detection of disease-relevant single nucleotide polymorphisms to the synthesis of well-defined substrates for the study of novel DNA repair processes
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Abasic (Ap) sites are a common form of DNA lesion that occur endogenously 50,000-200,000 per cell per day in mammals. The alkylation of the guanine and adenine residues...
The use of pluripotent stem cells as a model for early human placentation
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Throughout gestation, the placenta plays a critical role in ensuring proper development of the fetus. The placenta functions to exchange nutrients, oxygen, and fetal waste...
Palladium nanoparticles encapsulated with resveratrol-derived phenols and polyphenols for targeted prostate cancer therapy
(University of Missouri--Columbia, 2019)
The main goal of this dissertation was to explore the development of a new generation of green nanoformulations through the production of biocompatible palladium nanoparticles using resveratrol to treat, image and evaluate the efficacy...
Structural, biochemical, and inhibition studies of proline biosynthetic enzymes
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Pyrroline-5-carboxylate reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent reduction of [Delta]1-pyrroline-5-carboxylate (P5C...
Synthesis, characterization, and reactivity of actinide complexes bearing An-E bonds (An = Th, U; E = P, As)
(University of Missouri--Columbia, 2021)
-metal phosphinidiide complexes of the form {(C5Me5)2Th[[mu]2-P(Mes)][[mu]2-P(H)Mes]M(L)n}2 (L = THF, Et2O), where computational (DFT) analysis and 31P NMR spectroscopy suggests significant Th-P multiple bond character. Reaction of (C5Me5)2Th[P(H)Mes]2 with CuMes in a 2...
LC-MS/MS method development for quantitative analysis of cyanogenic glycosides in elderberry and lipid peroxidation products in mice
(University of Missouri--Columbia, 2021)
by restricted social communication and repetitive behaviors. Prenatal stress is critical in neurodevelopment and increases risk for ASD, particularly in those with greater genetic susceptibility to stress. Docosahexaenoic acid (DHA) is one of the most abundant...
Investigating reaction conditions for controlling the self-assembly of metal-seamed pyrogallol[4]arene nanocapsules
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Upon coordination to metal ions, C-alkylpyrogallol[4]arenes (PgCn, where n is the number of carbon atoms in the pendant alkyl chains), can be assembled into spherical metal...
Studies and synthetic methodology of Nampt inhibition
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The purpose of this research is to study and synthesize an array of a highly potent pharmaceuticals that can selectively cause apoptosis in various cancer cells and to synthesize...
Crossed-beam chemical reaction dynamics probed with universal and state resolved ion imaging
(University of Missouri--Columbia, 2018)
The main goal of chemical reaction dynamics is to unravel the intimate motions of individual atoms during a chemical transformation. This information must generally be inferred from indirect macroscopic measurement. Very ...
Synthesis and evaluation of [105]Rhodium (III) complexes of phosphine chelate systems
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] [Superscript 105]RH has attractive nuclear and chemical properties to be investigated as a nuclide for development of potential radiopharmaceuticals. Complexes of Rh...
Structural and kinetic studies of human aldh7a1 and aldh9a1
(University of Missouri--Columbia, 2021)
The regulation and detoxification of endogenously and exogenously derived aldehydes is paramount to cellular survival due to the highly reactive nature of aldehydes as electrophiles. Human aldehyde dehydrogenases (ALDHs) ...
Strategies for metal colloidal nancrystal synthesis in sustainable media
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Over the past decades, the Green Chemistry and Sustainability concept has aroused researchers to denounce their traditional ways of thinking regarding chemical processes...